1389 Local injection with anti-herpes simplex virus antibodies protects against development of herpes simplex virus–induced sweating disturbance

Background: The involvement of sweat glands in preventing dry skin mice has been suggested. We previously demonstrated that inoculating the thigh wild-type immunocompetent C57BL/6J (B6) with cutaneous herpes simplex virus-1 (HSV-1) led to infection glands, which turn caused sweating disturbance followed by development skin. Interestingly, HSV-1–inoculated recovered from showed neither HSV-1–induced zoster-like lesions nor significant second inoculation HSV-1, suggesting principal driver protection was immunity against HSV-1. Objective: investigated whether anti-HSV-1 antibodies protect and lesions. Methods: injected serum into footpads following HSV-1 at thigh. Using impression mold technique real-time PCR, we examined response together detection DNA skin, dorsal root ganglia (DRG) B6 mice. Results: Resistance proportional anti-HSV IgG titers. Local percutaneous injection antisera inoculated either live or heat-inactivated 7 days earlier protected disturbance, while control sera no such protection. This treatment also prevented viral spread replication DRG; not only but keratinocytes were tissue damage prior local sera. Conclusion: any site provided long-term induction disturbance–induced through subsequent challenge.